Paper-2 content
Protocols
1. Cell kinetic’s and differentiation :
- Keratinization
- Cell cycle
- Cutaneous cells cytokines
Clinical conditions
- Psoriasis
- Lichen planus
- Exfoliative dermatitis
- PRP
- Icthyosiform dermatoses
2. Drug reaction and contact dermatitis
- Mechanism of drug reaction
- Adverse cutaneous drug reaction.
- Allergic contact dermatiis
- Irritant contact dermatitis
3. Cutaneous photobiology
- Basic concepts about ultraviolet radiation
- Basic concepts about photo protection
4. Drug therapy in Dermatology
- General Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Drug metabolism
- Drug elimination
- Principles of topical drug therapy
- Cutaneous Manifestation of drug reaction
- Classifications ,mechanism,doses,and side effects of following drugs:
- Antihistamines
- Antimicrobials
- Antimalarial
- Antitubercular
- Antileprotic
- Cytotoxic
- Vasodilator
- Retinoids
- Antifungal
- Steroid
- Antivirals
- Biologics
- PUVA (topical & systemic)
- Topical agents like bleaching agents, sunblock, moisturizer, sclerosing agents, peeling agents etc.
5. Medical statistics
- Basic understanding of the usage and limitations of the common statistical tests used in reporting the results of research in clinical journals. The following lists of terms should give some idea of the range of terms and techniques which the candidate should understand:
- Research methodology & Definition and types
- Incidence
- Prevalence
- Sampling
- Survey
- Retrospective study
- Prospective study
- Control group
- Placebo
Descriptive statistics:
- Mean, median, mode
- Standard deviation, standard error
- Confidence interval
- Vanance
- Range, quartile, inter-quartile range Percentile
- Skewness
- Contingency table
- Population
- Missing values
- Outlines
Graphical techniques
- Histogram
- Box-plot
- Scattergram
Inferential techniques
- Null hypothesis
- Alternative hypothesis
- Parametric and non-parametric tests
- Normal distribution
- Type | and type 2 errors
- False positive and false negative
- Statistical power
- One and two-tailed tests
- Statistical significance, P value
- T-test
- Mann-Whitney and Wilcoxon test
- Chi-square test for 2 x 2 contingency table
- Correlation (Pearson’s and spearman’s)
- Linear regression
- Study design
Clinical trials
- Interpretation of simple clinical trial data
- Randomization
- Placebo-controlled trial
- Open trial
- Single-blind trial
- Double-blind trial
- Intention-to-treat
- Bias
Evidence-based medicine
- To have an understanding of evidence-based medicine and an ability to apply this understanding in the management of patients.
6. Functional organization of human body and internal environment including water and electrolyte balance.
- Cells as the living units of the body.
- Extracellular fluid of the internal environment.
- Homeostatic mechanisms of the major functional system.
- Control systems of the body.
7. Percutaneous absorption
- Mechanism of percuteneous absorption.
- Topical dermatological therapy and percutaneous absorption.
- Hazards of percutaneous drug absorption.
- Thermal regulation
- Physiology of skin appendages( apocrine, eccrine, sebaceous)
- Physiology, control and formation of formed elements
8. Endocrine system
Hypothalamus/pituitary
- The physiology and pathophysiology of control of pituitary secretion.
- Tests of pituitary hormone secretion.
- Pituitary disorders such as acromegaly, Prolactinoma and Cushing disease, hypopituitarism
Thyroid
- Thyroid hormone biosynthesis and its control.
- Clinical features of thyrotoxicosis and hypothyroidism.
Adrenal
- Hormone of adrenal gland
- Tests of adrenocortical function
- Addison's diseases and Cushing syndrome
Testis and ovary
- Etiology of hypogonadism, primary and secondary causes of male infertility related to medical diseases and treatment.
- Causes of erectile dysfunction and tts investigation
- Composition of semen.
- Testosterone and other male sex hormones
- Ovarian dysfunction and female infertility.
Parathyroid
- Control of calcium metabolism
- Causes of hypercalcimia and hypocalcimia
9. Metabolism
- Vitamins and related disorders
- Zinc and its related disorders
- Amyloid and its related disorders
- Porphyrias
- Lipid and related disorders
- Heavy metalsarsenic
- Mucin and related disorders.
10. Skin pigmentary disorders
- Vitiligo, Albinism
- Causes of generalised hyper pigmentation.
- Melasma
11. Sexual physiology
- Physiology of coitus.
- Menstrual cycle and ovulation.
- Spermatogenesis and fertilization
- Erectile dysfunction
- Sexual arousal
- Penetration
- Act
- Climex
- Ejaculation
- Exhaustation
- Premature ejaculation
- Male infertility
- Female infertility
- Vaginismus
- Frigidity
- Priapism