Paper-1 content

Paper-1 FCPS psychiatry:

Neuro-anatomy:

• Structure of the nerve, plasma membrane, nerve cell process. The types of cell found within nervous system. Neuronal synapses. The general anatomy of the brain, cranial nerves and spinal cord. Functions of the lobes and some major gyri including prefrontal cortex, cingulated gyrus and limbic system. The anatomy of the basal ganglia. The internal anatomy of the temporal lobes especially hippocampal formation, amygdala and reticular formation, the major white matter pathways, corpus callosum. Papez's circuit and other circuits relevant to integrated behavior. The major neurochemical pathways.

Neurophysiology:

• The basic concepts in the physiology of nervous system, synapses and receptors, including synthesis, release and uptake of transmitters. Basic knowledge of action potentials, resting potentials, ion fluxes and channels etc.
• The physiology of nervous system involved in integrated behavior including perception pain, memory, motor function, arousal, drives and the emotions including aggression fear and stress knowledge of disturbances of their functions with relevance to organic and nonorganic psychiatry.
• The localization of cerebral functions throughout the life span and their relevance to the effects of injury at different ages to the brain and behavior. An understanding of neurodevelopmental models of psychiatric disorders and of cerebral plasticity.
• A basic knowledge of the physiology of arousal and sleep with particular reference to noradrenergic activity and the locus ceruleus. Nature of dream and its relationship with sleep. The normal EEG and evoked response techniques. Their application in investigation of cerebral pathology, seizure disorders, sleep and psychiatric disorders. The effects of drug and different disorders on EEG.

Anatomy and Physiology of Endocrine System:

• Anatomic consideration of thyroid glands, formation and secretion of thyroid hormones, transport and metabolism of thyroid hormones, effect of thyroid hormones, regulation of thyroid secretion.
• Anatomie consideration of islets of Langerhans in the pancreas, biosynthesis and secretion of insulin, effects of insulin on various tissues, effects of intracellular glucose deficiency or insulin excess, Adrenal morphology, structure of medullary hormones, effects of catecholamines, regulation of adrenal medullary secretion, structure and biosynthesis of adrenocortical hormones, steroid biosynthesis, Action of ACTH. action of angiotensin II, transport, metabolism and excretion of adrenocortical hormones, effects of adrenal androgens and estrogens, Resistance to Stress, Regulation of glucocorticoid section (role of ACTH, adrenal responsiveness, circadian rhythm, the response to stress, glucocorticoid feedback).
• Morphology of Pituitary glands, Hormones secreted by Pituitary Glands and their effects.
• Anatomical consideration of gonads, Secretion of sex hormones, Function of sex hormones, Pituitary gonadotropin and prolactins.
• Anatomical consideration of pineal glands, Regulation and secretion of melatonin, Function of Pineal Glands.

Cellular structure (Neuro-histology) and Neuroembryology Cellular structure (Neuro-histology):

• Organization of the cell
• Physical structure of cell
• Functional system of cell
• Genetic control of protein synthesis, cell function and cell reproduction
• Cell division (mitosis, meiosis)
• The forms and characteristics of epithelial tissue, connective tissue, adipose tissue, nerve tissue, muscle tissue
• Structure of the nerve plasma membrane, nerve cell process
• The types of cell found within nervous system.
• Neuronal synopses

Neuroembryology:

• Neural tube and its histogenesis
• Development of the brain-cerebral vesicles and its primary divisions
• Derivatives of rhombencephalon, mesencephalon, prosencephalon
• The development of commissures
• The development of spinal cord, cranial nerves, spinal nerves and the neural crest, autonomic nervous system
• Histological differentiation of nerve cells, ghia cells, neural crest cells and myelination
• Congenital malformation of the brain and spinal cord

Genetics:

• Basie concepts, chromosomes, cell division, gene structure transcription and translation,normal genotype, pattern of inheritance. Traditional techniques Family, twin and adoptim studies, Techniques of molecular cloning and gene probes and others.
• Condition associated with chromosomal abnormalities and Mendelian disorders, disorders with multifactor inheritance Fragile X syndrome. Prenatal identification, chromosomal and DNA analysis. Genetic counseling. Molecular and genetic heterogeneity. Phenotype / genotype correspondence.