Hb Electrophoresis
Protocols
Hb Electrophoresis:
Interpretation
Causes of increase HbA2
Thalassaemia trait (HbA2 Ilevel is ~3.9-
6.5%).
Causes of HbA2 Decrease
• Iron deficiency.
• Thalassaemia.
↑HbF found in:
• B thalassaemia trait.
• B thalassaemia major.
Hereditary persistence of fetal
haemoglobin.
• Homozygous sickle cell disease (Hbss).
• Sickle/ B* thalassaemia (some cases).
Sickle/ B' thalassaemia (some cases).
• Juvenile chronic myeloid leukaemia.
Multiple myeloma (uncommon and
never measured).
Acquired aplastic anaemia.